Composition of human-specific slow codons and slow di-codons in SARS-CoV and 2019-nCoV are lower than other coronaviruses suggesting a faster protein synthesis rate of SARS-CoV and 2019-nCoV.
Identifieur interne : 000800 ( 2020/Analysis ); précédent : 000799; suivant : 000801Composition of human-specific slow codons and slow di-codons in SARS-CoV and 2019-nCoV are lower than other coronaviruses suggesting a faster protein synthesis rate of SARS-CoV and 2019-nCoV.
Auteurs : Chu-Wen Yang [Taïwan] ; Mei-Fang Chen [Taïwan]Source :
- Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [ 1995-9133 ] ; 2020.
Abstract
Translation of a genetic codon without a cognate tRNA gene is affected by both the cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs. Moreover, two consecutive slow codons (slow di-codons) lead to a much slower translation rate. Calculating the composition of host specific slow codons and slow di-codons in the viral protein coding sequences can predict the order of viral protein synthesis rates between different virus strains. Comparison of human-specific slow codon and slow di-codon compositions in the genomes of 590 coronaviruses infect humans revealed that the protein synthetic rates of 2019 novel coronavirus (2019-nCoV) and severe acute respiratory syndrome-related coronavirus (SARS-CoV) may be much faster than other coronaviruses infect humans. Analysis of host-specific slow codon and di-codon compositions provides links between viral genomic sequences and capability of virus replication in host cells that may be useful for surveillance of the transmission potential of novel viruses.
DOI: 10.1016/j.jmii.2020.03.002
PubMed: 32178970
Affiliations:
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Electronic address: ycw6861@scu.edu.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Microbiology, Soochow University, Shih-Lin, Taipei 111</wicri:regionArea><wicri:noRegion>Taipei 111</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Mei Fang" sort="Chen, Mei Fang" uniqKey="Chen M" first="Mei-Fang" last="Chen">Mei-Fang Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Taipei Veterans General Hospital, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi</title><idno type="eISSN">1995-9133</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Translation of a genetic codon without a cognate tRNA gene is affected by both the cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs. Moreover, two consecutive slow codons (slow di-codons) lead to a much slower translation rate. Calculating the composition of host specific slow codons and slow di-codons in the viral protein coding sequences can predict the order of viral protein synthesis rates between different virus strains. Comparison of human-specific slow codon and slow di-codon compositions in the genomes of 590 coronaviruses infect humans revealed that the protein synthetic rates of 2019 novel coronavirus (2019-nCoV) and severe acute respiratory syndrome-related coronavirus (SARS-CoV) may be much faster than other coronaviruses infect humans. Analysis of host-specific slow codon and di-codon compositions provides links between viral genomic sequences and capability of virus replication in host cells that may be useful for surveillance of the transmission potential of novel viruses.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Yang, Chu Wen" sort="Yang, Chu Wen" uniqKey="Yang C" first="Chu-Wen" last="Yang">Chu-Wen Yang</name></noRegion><name sortKey="Chen, Mei Fang" sort="Chen, Mei Fang" uniqKey="Chen M" first="Mei-Fang" last="Chen">Mei-Fang Chen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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